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Frame from Original Zoloft Commercial Plays via YouTube's privacy-enhanced embed

Original Zoloft Commercial

SuperBowlSammy
Other
YouTube
Cited on HN 4 times, 2019–2025, never outright recommended score 0
Years with an HN recommendation, 2007–2026

Mostly cited as a recognizable example of antidepressant advertising in debates about pharmaceutical marketing and the serotonin theory.

A one-minute animated commercial for the antidepressant Zoloft, described as the original that inspired later sequels and parodies.

1 citations · 3 critical · Other · partly dated

4 Hacker News comments

From the HN archive; up to 20 kept per video, favoring different commenters. Recommendations first.

@banads Jan 2020 Pushes back
on HN thread Medications that change who we are
>Citation required [this video] >"Depression may be related to an imbalance of natural chemicals between nerve cells in the brain. Prescription Zoloft works to correct this imbalance."

Video list and Hacker News comment labels from HackerTube (prompted by @karpathy), released under ODC-By 1.0, built on the open-index/hacker-news archive. Hacker News data is provided by Y Combinator; comments remain the work of their authors. Video titles, channel names and thumbnails belong to their creators and are shown via YouTube. HackerTube Watch is an unofficial edition. Data export of 2026-10-31.

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