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The Problem with America’s Lab Mice and Why it Should Matter to You

3 videos recommended on HN
YouTube
1 HN user recommended this podcast episode1 month2020–2021 score 1
Years with an HN recommendation, 2007–2026

HN links it when discussing mouse-study reliability and reproducibility.

A JRE clip in which Bret Weinstein explains his concern that most American lab mice descend from a single lab lineage. He argues this undermines how well mouse research translates to humans.

“Here's the actual segment (18 mins)” (HN, 2020)

1 recommendations · 3 citations · Podcasts

4 Hacker News comments

From the HN archive; up to 20 kept per video, favoring different commenters. Recommendations first.

@aaron695 Jul 2020 Recommends
on HN thread Cracking down on research fraud
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He specifically mentions comments like yours are not helpful. This is the researcher fraud that is the problem in science that we are talking about, issues at hand are ignored or twisted so the paper mill can continue. The concept is all mice in the USA come from one laboratory and have a common attribute that's different from wild mice and European suppliers. And it's spelt out how in theory this different attribute could change medical results. To come back with we don't care, without proof it's not a issue, is a deeply broken system, but is exactly how current universities work. Here's the actual segment (18 mins) - [this video] Related (12 mins) - [link]
Segment explaining US lab mice share one lab origin

Citations, criticism and jokes

@LinuxBender Nov 2020 Cites it
on HN thread Human ageing process biologically reversed in world first
There have been a few interviews with Bret Weinstein on this topic as it pertains to lab mice. [1] [2] I am curious if this is in any way related and would there be similar concerns around how humans deal with senescent cells and cancer if Telomere are artificially lengthened. Out of curiosity, does anyone in this field have more information to add to Bret's interview that can explain technically how the mice ended up with longer Telomere's and if it was on purpose? [1] - [link] [2] - [this video]
Bret Weinstein interview on lab mice concerns

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