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Fat Chance: Fructose 2.0

6 videos recommended on HN
YouTube
5 HN users recommended this lecture5 months2014–2024 score 5.5
Years with an HN recommendation, 2007–2026

Recommended as a follow-up to Lustig's original sugar talk for the metabolic details of fructose.

Robert Lustig of UCSF updates his sugar talk, arguing that fructose and processed foods drive obesity and metabolic syndrome through their endocrine effects. It is a roughly 90-minute university lecture.

“I'd highly recommend these two talks by Robert Lustig on the subject.” (HN, 2021)

1 strong recommendations · 4 recommendations · 1 citations · Lectures · partly dated

6 Hacker News comments

From the HN archive; up to 20 kept per video, favoring different commenters. Recommendations first.

@akurzon Feb 2021 Strongly recommends
on HN thread Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS
For anyone interested in a detailed explanation of fructose metabolism (and why it's bad for you), I'd highly recommend these two talks by Robert Lustig on the subject. The first one is about how the body reacts to fructose, and the second video is a follow-up that emphasizes how fructose has contributed to the obesity epidemic in the US and elsewhere. [link] [this video]
Detailed fructose metabolism and its role in obesity
@pkulak May 2014 Recommends
on HN thread Always Hungry? Here’s Why
If carbs are bad, sugar is horrible. Just in case you haven't seen these: Sugar: The Bitter Truth: [link] Fat Chance: Fructose 2.0: [this video]
Lustig on fructose
@halotrope Feb 2018 Recommends
on HN thread Obesity and Overweight Prevalence for the U.S
Read more
Sugar seems to be a major driver of this development. The main problem is likely excessive sugar and especially fructose consumption starting with the emerge of cheap HFCS in most products. Dr. Robert Lustig has put a lot of research into the causes of the obesity crisis. He goes into great detail in his lectures on YouTube [this video] He also argues against the "gluttony and sloth" prejudice by saying that you eat too much and move to little as a consequence of messed up hormones due to excessive fat. Not the other way around. The problem is probably more dimensional but the correlation between increasing Sugar/HFCS amounts in foods and the onset of obesity seems to be pretty strong.
Lustig explains sugar and hormones driving obesity
@aficiomaquinas May 2024 Recommends
on HN thread Japan: The land that doesn't need Ozempic
If by lifestyle you mean behavioral disorder, It seems to me that the science from the last 10 years is starting to point in the opposite direction. If I may recommend, there is a great presentation by Dr. Robert Lustig called "Fat Chance: Fructose 2.0". [0]: [this video]
Lustig presentation on fructose and behavior

Citations, criticism and jokes

@mrmuagi Nov 2020 Cites it
on HN thread Why Americans Have Been Deceived About Canada's Health Care System
I don't think having everybody insured would be the criteria for it being working either. I came across a lecture about how metabolic syndrome treatment accounts for a large chunk of health care spending (75% [0]), and there's a lot of blame put on added sugars and processed foods. A large push for preventative care would be ideal. [0] [this video]
Metabolic syndrome driving healthcare spending

Video list and Hacker News comment labels from HackerTube (prompted by @karpathy), released under ODC-By 1.0, built on the open-index/hacker-news archive. Hacker News data is provided by Y Combinator; comments remain the work of their authors. Video titles, channel names and thumbnails belong to their creators and are shown via YouTube. HackerTube Watch is an unofficial edition. Data export of 2026-10-31.

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