Joe Rogan Experience #1035 - Paul Stamets

As a lay person, it's not clear to me whether these malacidins were found in mycelium (fungi). I'm inclined to think this is likely. If so, finding them in dirt is not really surprising (30% of dirt is comprised of mycelium - living and dead). It seems like the obvious place to look for new antibiotics. For anyone that's interested in fungi I can't recommend listening to Paul Stamets talk on the subject more highly. Like a lot of people here on HN I take in a lot of information and his recent interview with Joe Rogan[0] was one of the most fascinating things I've come across in years. [0] [this video]

Bret Victor - Inventing on principle [link] Alan Kay - Power of Simplicity [link] Steve Jobs - Marketing (unveiling Think Different) [link] Robert Cialdini - On Influence [link] Peter Thiel - On Zero to One (Notes on Starts Ups or How to Build the Future) [link] Naval Ravikant on Reading, Happiness, Systems for Decision Making, Habits, Honesty and More (Farnam Street podcast) [link] Josh Wolfe - On "This is who you are up against" podcast [link] Richard Feynman - Fun to Imagine [link] Paul Graham - Startup school (2008) [link] James Burke - Connections (BBC documentary) <No link> Jim Al-Khalili tells the story of the Atom (BBC) [link] Elon Musk's 2003 Stanford University Entrepreneurial Thought Leaders Lecture [link] Ken Robinson - Do schools kill creativity? [link] Paul Stamets on mycology, bioremediation and fungi- Joe Rogan Experience [this video]

Joe Rogan Experience [0]. I love that he sits down with people and actually has long in-depth conversations with them. Here's a few interesting ones: * Let's start with his Elon Musk discussion [1]. It came out 2 weeks ago and it already has 14m views. They basically discuss a bunch of his ideas along with things such as AI and the future of humanity. It's fascinating to get a peek into the kind of person he is. * His discussion with Matthew Walker has been one of the most enlightening ones for me [2]. He's a sleep expert, and in the podcast they go over different myths relating to that. There was recently a HN post [3] where some people were quoting him and his book. * Another big favorite of mine was his discussion with Paul Stamets [4], a mycologist (i.e. a mushroom expert). They discuss some of the effects of different kinds of mushrooms, including psilocybin mushrooms (colloquially known as magic mushrooms). * I loved his discussion with Gary Johnson [5], the Libertarian Party's presidential candidate for 2016. How many other presidential candidates would you imagine would be willing to sit down and answer hard-hitting questions for +2 hours? He also had a discussion with Larry Sharpe [6], the Libertarian Party's candidate for governor of New York in 2018. Full disclosure: I recently joined the Libertarian Party. Listening to these podcasts pushed me to learn more about their movement. * He had a discussion with Mikhaila Peterson [7], the daughter of Jordan Peterson, whi

I studied engineering/physics and I've dipped into the agricultural field the past year having developed an interest in it, also observing the operations of a local organic farm. It's actually quite fascinating. I'm currently following a course created by Dr. Elaine Ingham, who is a microbiologist that studies soil biology and has done some really amazing research. She also worked at Colorado State University, which can't be a coincidence! Here's the lowdown of what happens, because we've been getting this wrong for centuries in agriculture. The nutrients (N, Ph, Mg, K, etc) are bound to materials in the soil ranging from rocks to pebbles, to sands, silts and clays. We have been destroying the soil by tilling practices and large machinery which are creating compaction layers that lead to anaerobic conditions causing the "good" biology in the soil to die and also preventing roots from growing to the depth they need. It turns out that the way that the nutrients become available to the roots of the plant is by means of the bacteria/fungi breaking their bonds from the previously mentioned materials (rocks, etc) and then, even more interestingly, they get eaten by higher trophic level predators who shit out the nutrients in plant available form! Some fun facts: - The roots release sugars (photosynthates) into the soil which attract particular bacteria/fungi based off its needs for nutrients AND pH requirements (bacteria release substances which raise pH and fungi acids which lower